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QClamp® is an ultra-sensitive qPCR assay detects below 0.1% mutant DNA

QClamp® Gene Mutation Detection Kits

QClamp® Gene Mutation Detection Kit is a highly sensitive qPCR assay that provides detection sensitivity of 0.1% or lower. It is ideal for screening rare and actionable somatic mutations in oncogenes. The assay utilizes a sequence-specific clamp (Xeno-Nucleic Acid probe) that suppresses PCR amplification of wild-type DNA template and selectively amplifies only mutant template. The kits provide a rapid, reproducible and affordable solution which employs a simple workflow and PCR machines that are commonly used in research and clinical labs.

Features and benefits


Ability to detect below 0.1% mutations


Suitable for liquid biopsy, FFPE tissue and more


Streamlined workflow with 3 hours turnaround time


Turnaround time ~ 2 hours

How it works

QClamp® is a revolutionary new way to screen for somatic mutations that utilize a sequence-specific clamp that suppresses PCR amplification of wild type template DNA. QClamp® allows selective PCR amplification of only mutant templates, which allows the detection of mutant DNA in the presence of a large excess of wild-type templates from a variety of samples including FFPE, liquid biopsy, and traditionally challenging cytology samples.

Supporting data

QClamp™ Detects below 0.1% mutated DNA
The most sensitive technology that could detect below 0.1% mutant in 2 hours.

QClamp™ HRM for EGFR Mutation
High-resolution melting (HRM) profiles of clinically relevant EGFR mutations generated by the QClamp EGFR Test.

Customer testimonial

Dr. Shidong Jia from Genentech

“QClamp® XNA technology is the most sensitive and detected mutations missed by …”

“Our lab did a good comparison study for BRAF mutations with all the technologies available in the market and found that QClamp® XNA technology is the most sensitive and detected mutations missed by all current methods including NGS and ddPCR. I strongly recommend this technology!”

Dr. Sumanta Goswami from Albert Einstein College of Medicine