Order Now 1-800-246-8878

Extraordinary structural stability with greater affinity, specificity and stringency

Xenonucleic Acid (XNA) Molecular Clamp Technology

DiaCarta scientists have developed innovative new nucleic acid molecular oligomers that hybridize by Watson-Crick base pairing to target DNA sequences yet have a modified chemical backbone. The xenonucleic acid oligomers (figure: Watson-Crick Base Pairing of DNA with cognate XNA) are highly effective at hybridizing to target sequences and can be employed as molecular clamps in quantitative real-time polymerase chain reactions (PCR) or as highly specific molecular probes for detection of nucleic acid target sequences.


  • Molecular clamps for qPCR
  • Synthetic oligomers containing natural A, T,C, G or modified nucleosides (15 to 25 nt long)
  • Hydrophilic and neutral backbone (no phosphate group like PNA)
  • Hybridization by Watson-Crick pairing
  • Resistant to any known nucleases
  • Much higher binding affinity
  • DNA binding is independent of salt concentration
  • Large melting temperature differential (ΔTm = 15-20ºC) in single-nucleotide (SNP’s) and insertion/deletions (indels) (5-7ºC for natural DNA)

Innovative applications powered by XNA technology


Gene Mutation Detection Test


Colorectal Cancer Mutation Detection Kit


NGS Targeted Sequencing Service Platform


Gene Editing Tests


Adapter Dimer Removal for NGS Library Preparation